In the background are eosinophils, increased myeloid precursors and increased small lymphocytes and plasma cells.
Cell A is a binucleate Reed‐Sternberg (RS) cells but can easily mis-diagnosed as a binucleate plasma cell (cell B). RS cells are characteristic of classical Hodgkin lymphoma. The diagnosis was confirmed by trephine biopsy with the Hodgkin and Reed‐Sternberg cells showing the typical immunophenotype: CD15+, CD30+, CD45− and CD20− .
RS cells are uncommonly seen due to the use PET staging and associated fibrosis in Hodgkin lymphoma.
Image credit – Parsons et al, AJH, 2020 https://doi.org/10.1002/ajh.25708
Subscribe today at Blood Academy to continue your learning