Lymphocyte module

LESSON OBJECTIVES

ACCESS THE COURSE MINDMAP

Red cell Inclusions

Howell-Jolly body

  • Single, dark inclusion located at the periphery of mature red cells.
  • It is formed from remnant DNA usually removed by the spleen.
  • Associated features that may also be seen include target cells, thrombocytosis, and pan-leucocytosis.
  • Seen
    • after surgical splenectomy
    • functional hypo or asplenism states associated with sickle cell disease,
    • thalassaemia, and coeliac disease

Figure 2.22 - Howell-Jolly body (blood)