) Multiple Choice & Extended Matching Questions


You are contacted by the on-call paediatric junior doctor who is concerned about a 6-year-old boy with sickle cell anaemia (HbSS) who was admitted with flu-like symptoms. The junior doctor noticed significant changes in the patient’s blood results over the last 6 months. 


You review his clinic letters and find that he had been started on hydroxycarbamide following recurrent hospital admissions for vaso-occlusive crises. 


Which of the following changes is least expected with hydroxycarbamide treatment? 


Please select ONE of the following options: 


MCV of 110


Increase in absolute reticulocyte count


Increase in HbF %


Rise in haemoglobin concentration


Reduction in white blood cell count

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